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Hospitalized patients with schizophrenia had twice as many caries and extracted teeth, and five time less filled teeth than healthy people. The patient’s age and taking antiparkinsonics were established as predictors of the increased DMF index in hospitalized patients with schizophrenia.

Background/Aim. Professional military personnel are exposed to a number of stressors during the war as well as in peacetime conditions that can cause some hidden or manifest disorders, especially anxiety and depression, but also the development of a burnout syndrome. The aim of our investigation was to determine the defense mechanisms and subjective assessment of quality of life and anxiety in professional military personnel of the Serbian Armed Forces with the burnout syndrome. Methods. The cross-sectional study included a total of 55 professional military personnel, from 25 to 55 years of age, without current mental problem. In the investigation, the Maslach Burnout Inventory (MBI), Defense Style Questionnaire (DSQ-40), World Health Organization Abbreviated Instrument for Quality of Life Assessment (WHOQOL-BREF) and Beck Anxiety Inventory were used. The statistical analysis included parametric and nonparametric descriptive statistics. Results. Emotional exhaustion and depersonalization were present in 10.9% of subjects and in 12.7% of subjects respectively, in moderate se može uticati na smanjenje anksioznosti i poboljšanje kvaliteta života. U težim slučajevima je potrebna i stručna pomoć, uključujući i psihoterapiju.

Individualisation of an amitriptyline dose regimen offers substantial advantages over non-individualised treatment. In our study, we have compared both clinical effects, adverse effects and plasma steady-state concentrations of amitriptyline in 15 patients with major depressive disorder divided in three groups; (i) patients in group A were taking non-individualised doses of amitriptyline; (ii) patients in group B were taking doses of amitriptyline individualised by modified Bayesian method; and (3) patients in group C were taking doses of amitriptyline individualised by the multiple point method. The treatment course was 8 weeks long, in the setting of a psychiatric clinic. The patients in group A were taking significantly higher doses throughout the treatment course; the initial doses for the patients in group B were higher than doses for the patients in group C, but after corrections based on measured steady-state plasma concentrations they became similar. While Hamilton score descended uniformly in all three groups, both adverse effects and steady-state plasma concentrations of amitriptyline were higher in non-individualised group during the whole treatment course. The results of our study suggest that the multiple points method is the most precise, but tedious and not practical. The modified Bayesian method with correction based on first measured plasma steady-state concentration of amitriptyline offers similar therapeutic outcome and adverse effects score combined with low cost and being easy-to-use.

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