Experimental data on densities, viscosities, and refractive indices of binary mixtures with 2-butanol and polyethylene glycols of different molecular weights, tetraethylene glycol dimethyl ether, or N-methyl-2-pyrrolidone, were determined in the temperature interval from 288.15 K to 323.15 K and at atmospheric pressure. Excess molar volumes, viscosity deviations, and deviations in refractive indices were computed from these data and correlated with the Redlich–Kister polynomial equation. The obtained results allowed the interpretation of specific inter- and intramolecular interactions.