This study investigated the influence of family stressors on depression among women in the Ketu-South Municipality in the Volta Region. The study used the descriptive survey design. The census method was used to select a sample of 70 women for the study. The Family Inventory of Life Events and Changes (FILE) and Beck Depression Inventory (BDI II) were used to collect data  for the study. The data collected were analysed using means, standard deviation, Pearson Product Moment Correlation Co- efficient,  and  Linear  Multiple  Regression.  The  study  revealed  that  the  prominent family  stressor  among  the  women  experiencing  depression  in  the  Ketu-South Municipality is loss of family members (overall mean of 4.22). In addition, the study revealed  that  family  stressors  significantly  contribute  to  depression  among  women (R=.749,  p=.039)  with  loss  of  family  members  being  the  highest  contributor  to depression  (Beta=2.123,  p=.037).  The  study  recommended  that  family  stressors should be controlled among women living with depression by the government and non-governmental agencies.