This article reviews the literature on genetic aspects of dental caries and provides a framework for the rapidly changing disease model of caries. The scope is genetic aspects of various dental factors affecting dental caries. The PubMed database was searched for articles with keywords 'caries', 'genetics', 'taste', 'diet' and 'twins'. This was followed by extensive handsearching using reference lists from relevant articles. The post-genomic era will present many opportunities for improvement in oral health care but will also present a multitude of challenges. We can conclude from the literature that genes have a role to play in dental caries; however, both environmental and genetic factors have been implicated in the aetiology of caries. Additional studies will have to be conducted to replicate the findings in a different population. Identification of genetic risk factors will help screen and identify susceptible patients to better understand the contribution of genes in caries aetiopathogenesis. Information derived from these diverse studies will provide new tools to target individuals and/or populations for a more efficient and effective implementation of newer preventive measures and diagnostic and novel therapeutic approaches in the management of this disease.Keywords: Cariology, genetics, heredity, immunity, saliva, twin.Abbreviations and acronyms: AMBN = ameloblastin; CSA = complex segregation analysis; DMF = decayed, missing, filled teeth; DMFS = decayed, missing, filled tooth surface; HLA = human leukocyte antigen; GWAS = genome-wide association studies; LTF = lactotransferrin; MBL = mannose-binding lectin; MHC = major histocompatibility complex; SNPS = single nucleotide polymorphisms.

No abstract

No abstract