The sensitivity of an antigen prepared from tumor extract in three concentrations was examined in patients with cancers of the larynx of different extent (T₁–T₄) with or without metastases. At the same time circulating immune complexes in the serum were investigated by the polyethylene glycol precipitation method. Positive antigen reactions were found in 34% of the cases examined and enhanced immune complexes alone in 66%. These results were compared before and after the operative procedures and their relationship to the phyto-haemagglutinin test was assessed. Differences in these results appeared to be related to the size of the tumors (T₁–T₄) and to the presence of metastases.

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In the last 3 years tumour antigens (TA) and immune complexes (IC) were examined in 33 respectively 83 patients with cancer of the larynx. These tests were repeated several times during treatment and during the checking period. Tumour antigens were prepared from squamous cell carcinoma of the larynx using a modification of the methods by Bloom et al. and Halliday. Immune complexes in the serum were determined by the polyethylene glycol (PEG) test. In some cases the sensitivity to antigen was changed during the observation period. Constantly elevated immune complexes speaks in favour of recurrence in most of our cases.