The growing population of COVID-19 survivors in second wave represents a clear challenge to clinicians and researchers to look beyond the search for a cure and to address the multifaceted needs of those living with and beyond diagnosis. Common complications that disrupt the psychosocial, physical aspects of life and multi systemic complication for adult. COVID-19 survivors after primary treatment include: fatigue, neurological, cardiovascular, hepatic impairment,ocular,dermatological manifestation,Oral manifestation,acute pancreatitis,musculoskeletal,renal and reproductory system complications. Psychosocial interventions,particularly group-based interventions,physical activity programs, continuous monitoring and prompt treatment have shown great promise in improving these outcomes.Future research will identify even bettertargeted, more efficacious, and more cost effective medication and vaccination policy to counter COVID-19 outcomes. Healthcare providers must realize that they serve as vital gatekeepers to services that will help optimize outcomes. Addressing these issues in the post-treatment period represents the new challenge to supportive care.