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Objective: To propose a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery and increased bioavailability in treating Huntington’s disease (HD).Methods: We conducted a literature review of the pathophysiology of HD and the limitations of currently available medications. We also reviewed the potential therapeutic benefits of engeletin, a flavanol glycoside, in treating HD through the Keap1/nrf2 pathway. We then proposed a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery across the blood-brain barrier (BBB) and increased bioavailability.Results: HD is an autosomal dominant neurological illness caused by a repetition of the cytosine-adenine-guanine trinucleotide, producing a mutant protein called Huntingtin, which degenerates the brain’s motor and cognitive functions. Excitotoxicity, mitochondrial dysfunction, oxidative stress, elevated concentration of ROS and RNS, neuroinflammation, and protein aggregation significantly impact HD development. Current therapeutic medications can postpone HD symptoms but have long-term adverse effects when used regularly. Herbal medications such as engeletin have drawn attention due to their minimal side effects. Engeletin has been shown to reduce mitochondrial dysfunction and suppress inflammation through the Keap1/NRF2 pathway. However, its limited solubility and permeability hinder it from reaching the target site. A theoretical formulation of engeletin-nanostructured lipid nanocarriers may allow for free transit over the BBB due to offering a similar composition to the natural lipids present in the body a lipid solubility and increase bioavailability, potentially leading to a cure or prevention of HD.Conclusion: The theoretical formulation of engeletin-nanostructured lipid nanocarriers has the potential to improve delivery and increase the bioavailability of engeletin in the treatment of HD, which may lead to a cure or prevention of this fatal illness.

“Katarni Rice” is the most prevalent, ceremonial and finest quality scented rice of Bihar. It is famous for its aromatic flavour, palatability and chura (beaten rice) making qualitiesofGeographical area of production of Katarni Rice includes districts of Munger, Banka and South Bhagalpur of Zone IIIA of Bihar. The unique features of Katarnirice is developed only when it is grown in its territory areas. It has an immense scope of trading in local as well as export market. But, the available Katarni rice is poor yielder (25-30 t/ha) and farmers are tending towards the cultivation of non-aromatic high yielding rice varieties. Hence, in order to save this landrace from extinction and promote and protect the interest of Katarni growers, attempts were made to get its geographical indication (GI). With objective of providing exclusive right to the farmers for growing this premium quality rice and getting remunerative price through its marketing, an application for getting the tag of geographical indication was submitted by a Katarnigrowers’ association. Bihar Agricultural University, Sabour as a technical facilitator for this application, served to characterize and document this rice landrace on the basis of morphological, biochemical and genetical traits. The present study deals with purification, documentation and characterization of Katarni rice which helped in getting the GI tag in 2018 from the office of Intellectual Properties Rights, New Delhi, India.

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