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Clerodendrum colebrookianum Walp is a perennial shrub which is native to South and Southeast Asia. Traditionally, it is used in the treatment of various diseases due to its immense therapeutic potential. It is widely used by the indigenous people of Northeast India as a remedy for treatment of various diseases like diabetes, hypertension, stomachache, jaundice, cough and rheumatism. The plant possesses different biologically active components like Colebrin A, Colebrin B, Colebrin D, Colebrin E, β-Sitosterol etc. This review reported various pharmacological activities of the plant such as antihypertensive, anti-inflammatory, analgesic, hepatoprotective, antioxidant, anthelmintic and some other activities which provide scientific evidence for some traditional therapeutic claims.