Objective To evaluate materno-fetal outcomes in pregnant women with jaundice. Methods A prospective study was conducted over a period of 6 months in a tertiary care hospital of Delhi, India. 82 pregnant women with jaundice were included. The serum was screened for viral markers, liver function tests, and coagulation status. Results The mean age of women was 27.3 ± 4.3 years. 43.9 % (n = 36) women were HEV positive, 36 % (n = 27) HBsAg positive, 4 % (n = 3) HAV positive and 1.3 % (n = 1) HCV positive. Intrahepatic cholestasis was diagnosed in 10.8 % (n = 8) of women. Maternal morbidity was evaluated in terms of chorioamnionitis (5.4 %, n = 3), encephalopathy (26.8 %, n = 15), and coagulopathy (67.9 %, n = 38). There were five maternal deaths, and all were unbooked with HEV-positive status and a bilirubin [15 mg/dl with deranged coagulogram and encephalopathy and IUDs. 79 women delivered vaginally, and three had cesarean section. Of the vaginal deliveries, 59.8 % (n = 49) went into spontaneous labor, and 25.5 % (n = 21) were induced for varied reasons (BPS \ 6/10 (38 %, n = 8)) and progressive derangement of LFT (38 %, n = 8). Among the 71 deliveries, 29 (40.8 %) were IUD and 42 (59.1 %) were live born. On analyzing the morbidity data, it was found that HEV-positive women (deranged coagulogram 71.05 %, IUD 75.86 %, encephalopathy 80 %) had a poorer outcome as compared to their HBsAg positive counterparts (deranged coagulogram 10.52 %, IUD 13.79 %, encephalopathy 6.66 %).
Genital tract tuberculosis is usually secondary to extragenital tuberculosis. The upper genital tract is usually involved; involvement of cervix and vulva is very uncommon. We present two such rare cases of vulval and cervical tuberculosis diagnosed on histopathology and treated with antitubercular chemotherapy.
A 24-year-old unbooked G 2 P 1 L 0 (2 nd gravida, para 1 but no living issue) presented at 6 months amenorrhea with increased Blood Pressure (BP) records. She was diagnosed Pemphigoid Gestationis (PG) in her first pregnancy after confirmation on skin biopsy and direct immunofluorescence (DIF) [Table/ Fig-1]. There were no postpartum flare-ups though she continued irregular and self medication of prednisolone. On examination, there were fresh bullous lesions along with old healed scar marks on the abdomen and limbs [Table/ Fig-2,3]. Uterus corresponded to 24-26 weeks of gestation with a single live fetus. She was started on antihypertensive drugs and dermatology review was done. Prednisolone (15 mg OD) was started. Strict maternofetal surveillance was done. Her haemogram, RFT, liver function tests, fundus and ultrasound for kidneys were normal. Due to uncontrolled BP, decision for termination was taken. Patient delivered a still birth weighing 750 gm. No postpartum flare ups of PG were noted. She was discharged on prednisolone in a satisfactory condition. DisCussionPemphigoid Gestationis (PG) also known as herpes gestationis is a rare autoimmune blistering disease with an incidence of 1/50000 pregnancies [1]. Presentation in the second or third trimester is most common and tends to recur in subsequent pregnancies Keywords: Autoimmune Pemphigoid Gestationis (PG) is a rare autoimmune blistering disease with an incidence of 1/50000 pregnancies. Presentation in the second or third trimester is most common and tends to recur in subsequent pregnancies with earlier onset and a more severe course. Direct Immunofluorescence (DIF) staining is confirmatory on skin biopsy specimen. A 24-year-old female presented at 6 months period of gestation with increased blood pressure records. On examination, there were fresh bullous lesions along with old healed scar marks on the abdomen and limbs. Termination of pregnancy was done due to high BP. Patient delivered a fresh still birth weighing 750 gm. No postpartum flare ups were seen and she was discharged on prednisolone in a satisfactory condition.
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