Background With the emergence of SARS‐CoV‐2, influenza surveillance systems in Spain were transformed into a new syndromic sentinel surveillance system. The Acute Respiratory Infection Surveillance System (SiVIRA in Spanish) is based on a sentinel network for acute respiratory infection (ARI) surveillance in primary care and a network of sentinel hospitals for severe ARI (SARI) surveillance in hospitals. Methods Using a test‐negative design and data from SARI admissions notified to SiVIRA between January 1 and October 3, 2021, we estimated COVID‐19 vaccine effectiveness (VE) against hospitalization, by age group, vaccine type, time since vaccination, and SARS‐CoV‐2 variant. Results VE was 89% (95% CI: 83–93) against COVID‐19 hospitalization overall in persons aged 20 years and older. VE was higher for mRNA vaccines, and lower for those aged 80 years and older, with a decrease in protection beyond 3 months of completing vaccination, and a further decrease after 5 months. We found no differences between periods with circulation of Alpha or Delta SARS‐CoV‐2 variants, although variant‐specific VE was slightly higher against Alpha. Conclusions The SiVIRA sentinel hospital surveillance network in Spain was able to describe clinical and epidemiological characteristics of SARI hospitalizations and provide estimates of COVID‐19 VE in the population under surveillance. Our estimates add to evidence of high effectiveness of mRNA vaccines against severe COVID‐19 and waning of protection with time since vaccination in those aged 80 or older. No substantial differences were observed between SARS‐CoV‐2 variants (Alpha vs. Delta).

Most cases did not fulfil severity criteria, which illustrates the low compliance of monitoring protocols in sanitary care system.

Background: With the emergence of SARS-CoV-2, influenza surveillance systems in Spain were transformed into a new syndromic sentinel surveillance system. The Acute Respiratory Infection Surveillance System (SiVIRA in Spanish) is based on a sentinel network for Acute Respiratory Infection (ARI) surveillance in Primary care, and a network of sentinel hospitals for Severe ARI (SARI) surveillance in hospitals. Methods: Using a test-negative design and data from SARI admissions notified to SiVIRA between January 1 and October 3, 2021, we estimated COVID-19 VE against hospitalization, by age group, vaccine type, time since vaccination and SARS-CoV-2 variant. Results: VE was 89% (95% CI: 83-93) against COVID-19 hospitalization overall in persons aged 20 years and older. VE was higher for mRNA vaccines, and lower for those aged 80 years and older, with a decrease in protection beyond 3 months of completing vaccination, and a further decrease after 5 months. We found no differences between periods with circulation of Alpha or Delta SARS-CoV-2 variants, although variant-specific VE was slightly higher against Alpha. Conclusions: The SiVIRA surveillance system, with a network of sentinel hospitals in Spain was able to describe clinical and epidemiological characteristics of SARI hospitalizations, monitor the circulation of SARS-CoV-2 and other respiratory viruses, and provide data to measure the effectiveness of COVID-19 vaccination in the population under surveillance. Our results add to evidence of high VE of mRNA vaccines against severe COVID-19 and waning protection with time since vaccination.

Background: With the emergence of SARS-CoV-2, influenza surveillance systems in Spain were transformed into a new syndromic sentinel surveillance system. The Acute Respiratory Infection Surveillance System (SiVIRA in Spanish) is based on a sentinel network for Acute Respiratory Infection (ARI) surveillance in Primary care, and a network of sentinel hospitals for Severe ARI (SARI) surveillance in hospitals. Methods: Using a test-negative design and data from SARI admissions notified to SiVIRA between January 1 and October 3, 2021, we estimated COVID-19 VE against hospitalization, by age group, vaccine type, time since vaccination and SARS-CoV-2 variant. Results: VE was 89% (95% CI: 83-93) against COVID-19 hospitalization overall in persons aged 20 years and older. VE was higher for mRNA vaccines, and lower for those aged 80 years and older, with a decrease in protection beyond 3 months of completing vaccination, and a further decrease after 5 months. We found no differences between periods with circulation of Alpha or Delta SARS-CoV-2 variants, although variant-specific VE was slightly higher against Alpha. Conclusions: The SiVIRA surveillance system, with a network of sentinel hospitals in Spain was able to describe clinical and epidemiological characteristics of SARI hospitalizations, monitor the circulation of SARS-CoV-2 and other respiratory viruses, and provide data to measure the effectiveness of COVID-19 vaccination in the population under surveillance. Our results add to evidence of high VE of mRNA vaccines against severe COVID-19 and waning protection with time since vaccination.

Results Lower socioeconomic status, lower per capita income and presence of <20 years old in the household were associated with FI. Of the four dietary patterns identified, "prudent" (dairies, cracker, fruits and meat), "traditional" (rice, beans, vegetables, bread, butter and sugar), "snack" (salty snacks, sandwich cookies and chocolate) and "western" (fast food, processed meat, eggs, sweet-drinks), FI was associated positively with "snack" and negatively with "prudent" and "traditional". After controlling for potential confounders, FI remained associated positively with "snack" pattern and negatively with "prudent" pattern. Conclusion In pregnant women, FI play an important role on the food choices. Identifying high risk groups might be useful to trace public health policies concerning nutritional education and supplementation. Introduction Skin cancers, in particular squamous cell carcinoma and basal cell carcinoma, are the most frequent malignancies in organ transplant recipients (OTR). However, it is unclear if specialist OTR dermatology clinics increase the knowledge and attitude towards ultraviolet protection. Methods Using the same questionnaire on skin cancer awareness, history of ultraviolet exposure and use of protection measures before and after transplantation we compared two centres with a dedicated dermatology clinic (London) and with a fortnightly OTR dermatology clinic attended only by patients referred by the renal team (Oxford). Results Overall, 288 and 274 Caucasian transplant patients from Bart's and the London NHS trust and from Oxford Radcliffe Hospitals were recruited, respectively. As expected, 57% of OTR patients in Oxford had never seen a dermatologist compared to 17% in London (p<0.0001). Overall, OTR patients from Oxford where no dedicated skin clinic is available reported significantly (p<0.05) higher UV exposure, lower compliance to sunscreen use and lower knowledge on skin cancer than OTR patients from London where this facility is provided. Conclusions We found that dedicated OTR dermatology clinic improve substantially skin cancer awareness and photoprotective measures. However, this study could not estimate the impact of these clinics on skin cancer incidence, morbidity and mortality. WITHDRAWN P1-146 THE IMPACT OF DEDICATED DERMATOLOGY SERVICES ON THE AWARENESS OF CUTANEOUS CANCER RISK AND ON ATTITUDES TOWARDS UV EXPOSURE AMONG TRANSPLANT RECIPIENTS