This research combined GIS, Remote sensing and geophysical methods for groundwater potential investigation. The study aimed at delineating groundwater potential zones within Ilora, Oyo central, Nigeria. Unavailability of water is a major menace in these area and agricultural activities are suffering as a result. Landsat 8 OLI, ASTER DEM, geological, geophysical, and soil data of the research area were acquired for this study. In order to map groundwater potential of the area, eight thematic layers that influence groundwater occurrences and movement controlling factors such as, geology, elevation, slope, land use land cover (LULC), fault proximity, soil, lineament density, and drainage density were mapped out from the acquired data of the area. The influence of each theme and sub unit/class to groundwater recharge based on previous studies was evaluated using Analytical Hierarchical Process (AHP). The groundwater potential of the area of study was qualitatively classified into five classes, namely; very high, high, moderate, low, and very low which account for 0.3%, 7.8%, 54.8%, 35.6%, and 1.5% of the total area respectively. The results were cross-validated using well data from the area and 89% correlation was achieved. The groundwater potential map generated in this research could be used as a preliminary reference in selecting suitable sites for groundwater resource exploitation in the area in order to ameliorate the current scarcity of water in this region.