Locked volar plating is the most common surgical procedure to address distal radius fractures. The extended flexor carpi radialis approach continues to be an excellent method for visualizing distal radius fractures and applying a volar plate. A new understanding of the anatomy allows for better visualization and reduction of the many different distal radius fracture patterns surgeons commonly see. Within the extended flexor carpi radialis approach, we describe the radial septum in further detail including the anatomy which comprises the radial septum triangle. Knowledge of this area allows for better visualization, more anatomic reductions, and fewer complications.

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A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibodies, a birth-dose of HepB might also induce polyfunctional CD4+ T-cells, which may contribute to initial protection. We investigated whether vaccination with HepB in the first week of life induced detectable antigen-specific CD4+ T-cells after only a single dose and following completion of the entire HepB vaccine schedule (3 doses). Using HBsAg- stimulated peripheral blood mononuclear cells from 344 infants, we detected increased populations of antigen-specific polyfunctional CD154+IL-2+TNFα+ CD4+ T-cells following a single birth-dose of HepB in a proportion of infants. Frequencies of polyfunctional T-cells increased following the completion of the HepB schedule but increases in the proportion of responders as compared to following only one dose was marginal. Polyfunctional T-cells correlated positively with serum antibody titres following the birth dose (day30) and completion of the 3-dose primary HepB vaccine series (day 128). These data indicate that a single birth dose of HepB provides immune priming for both antigen-specific B- and T cells

The overarching goal of the Expanded Program for Immunization Consortium - Human Immunology Project Consortium (EPIC-HIPC) is to identify and characterize vaccine-induced neonatal responses and define biomarkers that may predict immunogenicity. Key to this effort is the establishment of the Data Management Core (DMC) to provide reliable clinical data and bioinformatic infrastructure for centralized curation, storage, and analysis of multiple deidentified ‘omics datasets. The DMC established a cloud-based platform to track, store, and share data according to set standards using Amazon Web Services (AWS). In our clinical core sites, biosamples collected and shipped across sites are tracked using ItemTracker via AWS Elastic Compute Cloud while their associated clinical data are captured using Research Electronic Data Capture software. Multi-omic datasets are stored in access-regulated Amazon Simple Storage Service (S3) for file version control. All data must complete quality control (QC) processes by the site generating said data, which is then exported to the DMC for quality assurance (QA). Data integration is performed using RStudio Server Pro which directly imports the data files from Amazon S3 via a controlled computing environment. The DMC deposits finalized datasets onto public repositories to be shared openly upon publication. Completion of our goal will provide the resources, planning, and scientific expertise to make this discovery platform possible. Robust DMC operations will allow rapid sharing of integrative results across the entire team. Maintenance of standards and public deposition of high quality ‘omics data will further advance scientific progress for the benefit of vaccine development and public health.