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Background Molluscum contagiosum virus (MCV) is a benign, common cutaneous infection predominantly affecting the younger pediatric population. Traditional treatments may be time consuming with variable efficacy. Time to spontaneous resolution is variable and treatment is often sought to shorten duration of infection, prevent further autoinoculation, prevent infectious spread to others and treat cosmetic intolerability. Case presentation We present the case of two patients with complete, simultaneous clearance of their molluscum contagiosum infections after receiving a routine 2018 quadrivalent influenza vaccination. Neither patient has had recurrence of molluscum contagiosum or permanent scarring. We review trials of intralesional immunotherapy in treatment of cutaneous infections to theorize the mechanism of MCV infection clearance post influenza vaccination. Conclusion We propose a delayed-type hypersensitivity reaction was induced as a heterologous effect of the influenza vaccination, similar to that seen in current immunotherapy treatments. This is the first reported case of MCV-directed immune reaction with infection clearance after influenza vaccination.

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In two randomized double-blind studies, twice-daily GSP301 nasal spray-a fixed-dose combination of olopatadine hydrochloride and mometasone furoate-significantly improved reflective total nasal symptom score (rTNSS) versus placebo (primary endpoint; presented elsewhere). GSP301 onset of action and reflective total ocular symptom scores (rTOSS) are presented here. METHODS: In each study (study 1 [NCT02631551]; study 2 [NCT02870205]), patients > _12 years with seasonal allergic rhinitis (SAR) were equally randomized to GSP301 (olopatadine 665mg/mometasone 25mg BID), olopatadine (665mg BID), mometasone (25mg BID), or placebo for 14 days. GSP301 onset of action was assessed by mean change from baseline in average instantaneous TNSS (iTNSS) at various timepoints (from 15 minutes to 4 hours post-dose) versus placebo and analyzed via mixed-effect model repeated measures, adjusting for covariates. RESULTS: A total of 1,180 and 1,176 patients were randomized in studies 1 and 2, respectively. A rapid onset of action for GSP301 was observed at 15 minutes post-dose versus placebo in study 1 (least squares mean difference [95%

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