Background: E-learning is described as the electronic transmission of a learning, training, or education program. It entails the use of a computer or other electronic device, such as a cellphone, to give training, education, or learning materials in some form. The development of e-learning at the university level necessitates a support system from lecturers, students, and technology professionals, as e-learning are in high demand in the learning process. However, knowing the adoption drivers as well as the primary problems that contemporary e-learning systems confront is necessary for successful use. Aim: The current study was conducted to investigate the relationship between E-Learning perception, effectiveness and factors affecting its quality among nursing students. Research design: Non-experimental descriptive correlational research design was used in conducting this study. Setting: The study was implemented at Faculty of Nursing, Menoufia University, Menoufia governorate. Sample: A simple random sample of 856 nursing students was recruited from faculty of nursing, Menoufia University. They accept to participate in the study. They were in 1 st , 2 nd , 3 rd , and 4 th grade. Tools: Three tools were used namely; Elearning Perception scale, effectiveness of E-learning scale, and Factors Affecting the Quality of E-Learning scale. Results: response of nursing students' of total e-learning perception, e-learning effectiveness, and factors affecting the quality of e-Learning levels all were at a moderate level. There was a highly statistically significant positive link between students' perceptions of e-learning, its effectiveness, and the elements impacting its quality among students. Conclusion: a highly significant positive correlation between students' Perceptions of E-learning, the effectiveness of e-learning, and the factors affecting the quality of e-Learning among students were found (P-value < 0.05). Also, nursing students' response of total of e-learning perception, e-learning effectiveness, and factors affecting the quality of e-Learning levels all were at a moderate level. Recommendations: The use of e-learning courses in educational institutions should be guided by both governmental and institutional support in order to improve learning opportunities for students and improve learning outcomes and skills, provide adequate in-service training for instructors on how to manage E-learning, and conduct training programs for students on how to use elearning platforms and tools.
