Background and aim: Acute pancreatitis (AP) is one of the leading causes of hospital admission from gastrointestinal diseases, with approximately 300,000 emergency department visits each year. Outcomes from acute pancreatitis are influenced by risk stratification, fluid and nutritional management, follow-up care, and risk-reduction strategies. Objective: The current work aimed to assess the pattern and outcome of acute pancreatitis. Patients and methods: A total of 70 patients with acute pancreatitis were enrolled. Those patients were subjected to history and clinical evaluation. All baseline laboratory and radiological data were recorded. Results: Serum albumin was negatively correlated with the length of hospitalization. Severe inflammatory response syndrome was associated with higher C-reactive protein and serum albumin level, in the Contrast-enhanced CT (CECT) scan and systemic inflammatory response syndrome (SIRS) in the first 48 hours were significantly associated with severe inflammation and necrosis. Conclusion: Acute pancreatitis is a challenging condition, which vary in severity and duration. Early diagnosis and severity classification have substantial impact on proper care. A more complicated disease is associated with the early onset of systemic inflammatory response syndrome.