Purpose: To compare the effi cacy and safety of available selective serotonin reuptake inhibitors (SSRIs) in order to fi nd the most effective drug with the least number of side effects in treatment of premature ejaculation (PE). Materials and Methods: This study was a randomized clinical trial. Four hundred and eighty patients with PE in the 4 groups referred to Imam Reza hospital Tehran, Iran from July 2018 to February 2019 were enrolled in the study. The patients received sertraline 50mg, fl uoxetine 20mg, paroxetine 20mg and citalopram 20mg, every 12 hours daily. The intravaginal ejaculatory latency time (IELT) before treatment, fourth and eighth weeks after treatment was recorded by the patient's wife with a stopwatch. Results: Mean IELT before, 4 and 8 weeks after treatment in four groups were: sertraline 69.4±54.3, 353.5±190.4, 376.3±143.5; fl uoxetine 75.5±64.3, 255.4±168.2, 314.8±190.4; paroxetine 71.5±69.1, 320.7±198.3, 379.9±154.3; citalopram 90.39±79.3, 279.9±192.1, 282.5±171.1 seconds, respectively. The ejaculation time signifi cantly increased in all groups (p <0.05), but there was no signifi cant difference between the groups (P=0.75). Also, there was no signifi cant difference in drugs side effects between groups (p >0.05). The most common side effects were drowsiness and dyspepsia, which were not severe enough to cause discontinuation of the drug. Conclusions: All available SSRIs were effective and usually had no serious complications. In patients who did not respond to any of these drugs, other SSRI drugs could be used as a salvage therapy.
Background: Nowadays, parents are paying more attention to the penis size of their children, especially obese children. Objectives: The aim of this study was to investigate the correlation between obesity, testosterone, and estradiol in prepubertal non-obese and obese children with micropenis. Methods: This case-control study was done on 58 non-obese and 86 obese micropenis children aged 8 - 13 years at Golestan Hospital, Tehran, Iran, from June 2018 to May 2020. The body mass index (BMI), testosterone and estradiol levels, stretched penile length (SPL), and the correlation between these were studied. Results: The mean age of children in non-obese and obese groups was 10.2 ± 1.34 and 10.5 ± 1.6 years, respectively. SPL in non-obese and obese subjects was 3.1 ± 1.3 and 2.9 ± 1.22 cm, respectively. SPL in both groups was significantly correlated with height and testosterone (height: r = 0.239, P = 0.009; testosterone: r = 0.344, P = 0.001) but not with BMI, weight, and estradiol. After the adjustment for age, BMI, weight, and estradiol, adjusted odds ratio with confidence interval 95% for penile length across to height and testosterone levels in non-obese group was 1.52 (0.91 - 1.83; P = 0.001) and 0.56 (0.36 - 0.98; P = 0.001), respectively and in the obese group was 1.42 (0.81 - 1.66; P = 0.001) and 0.75 (0.51 - 0.87; P = 0.001), respectively. Conclusions: Penile length is positively correlated with height and testosterone but not with weight and estradiol in non-obese and obese children. It is probably not essential and obligatory to recommend weight loss for this issue and weight loss should not be concerned by children and their parents.
Background: Most issues of micropenis boys include poor body image and quality of life. Objectives: The purpose of this assay was to survey the relationship of anthropometric measures, testosterone, estradiol, gonadotropins and prolactin with stretched penile length (SPL) and flaccid glans-pubis length (GPL) in pre-pubertal boys with true small penis. Methods: This was prospective a cross-sectional observational study that was conducted in Imam Reza Hospital, Tehran, Iran from February 2015 to May 2020. The pre-pubertal children 7 - 14 years who referred with small penis size were evaluated by a pediatrician and urologist and, if they had true micropenis, they were enrolled in the study (n = 236). The anthropometric and hormonal measurements, SPL, GPL, and relationship of these variables were evaluated. Results: Mean ages of children were 11.65 ± 1.59 years. Mean SPL and GPL were 2.95 ± 1.23 and 2.29 ± 1.06 cm, respectively. There was a significant relationship between SPL and GPL (r = 0.976, P = 0.000). SPL and GPL were not correlated with BMI (r = -0.182, P = 0.054; r = -0.161, P = 0.089, respectively). A significant correlation was found between SPL and GPL with height, FSH, LH, Testosterone and T/E ratio (P < 0.01) but no correlation with weight, estradiol and prolactin (> 0.05). Conclusions: According to the finding of present study, the flaccid measurement can be as helpful as stretched measurement if it is done from pubic bone to tip of glans. Retraining of primary health workers about age-related penile length may be reducing the misdiagnosis of micropenis and concerns of parents, especially in obese boys. The penile length in prepubertal children was not related to BMI and weight but was significantly related to height. Furthermore, Estradiol level is not related to penile length in children with micropenis.
IL-22 is elevated and associated with CD38 and Zap-70 expression in patients with CLL. No significant correlation was found between expression of CD38 and increased levels of IL-17A, negative expression of ZAP-70 showed a significant association with increased levels of IL-17A. © 2016 International Clinical Cytometry Society.
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