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Purpose:To compare visual performance in eyes with intraocular lenses (IOLs) that filter short-wave blue light versus contralateral eyes with IOLs that do not filter visible blue light.Methods:In this prospective, assessor-masked study that was conducted at five clinics in the US, eligible candidates were at least 12 months postimplantation of a control IOL and a contralateral IOL that filtered blue light. Glare disability was defined as the intensity of a white-light annulus that obscured a subject’s ability to see a central target. Heterochromatic contrast thresholds were defined as the intensity of a blue-light disk that obscured a central target. Photostress recovery time was the duration required to regain sight of the target after a five-second flash of annulus light.Results:Fifty-two subjects were evaluated. Mean glare disability was significantly less (P = 0.04) in the blue-filtering IOL group (1.97 ± 0.44 log μW/cm2) than in the control group (1.88 ± 0.43 log μW/cm2). Mean heterochromatic contrast threshold was significantly higher (P = 0.0003) in the blue-filtering IOL group (0.36 ± 0.43 log μW/cm2) than in the control IOL group (0.15 ± 0.49 log μW/cm2). Geometric mean photostress recovery time was significantly faster (P = 0.02) in the blue-filtering IOL group (21 ± 3 seconds) than in the control IOL group (26 ± 3 seconds).Conclusions:Glare disability was significantly lower, heterochromatic contrast threshold was significantly better, and recovery from photostress was significantly faster in the eyes with blue-filtering IOLs than in the contralateral control eyes with IOLs that did not filter blue light.

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