A case control study was carried out in the Department of Biochemistry, BSMMU from January to December 2007 to evaluate the association of uric acid with cerebrovascular disease (CVD) in a Bangladeshi population. A total number of 135 subjects of both sexes were grouped as group-I (CVD cases) and group-II (Healthy controls). Group-I include 85 cases, 59 were ischaemic cerebrovascular disease (ICVD) and 26 were haemorrhagic cerebrovascular disease (HCVD). By taking the history and doing the clinical examination and laboratory investigations diabetes mellitus, malignant disease, renal disease, thyroid disorder, liver disease & diuretic medication were excluded from study subjects. Serum uric acid was measured in all study subjects. The mean serum uric acid concentration of CVD, ICVD, HCVD cases and control subjects were 5.98±1.52 mg/dl, 6.04±1.45 mg/dl, 5.85±1.68 mg/dl & 5.00±1.35 mg/dl respectively. Serum uric acid found significantly increased in CVD, ICVD and HCVD cases in comparison to control subjects. No difference was found in serum uric acid in between ICVD and HCVD cases. Key words: Uric acid; cerebrovascular disease; ischemic cerebrovascular disease; haemorrhagic cerebrovascular disease. DOI: 10.3329/jdmc.v18i1.6299 J Dhaka Med Coll. 2009; 18(1) : 15-19

Community- acquired pneumonia (CAP) is a common condition with a significant mortality. Levofloxacin is recommended for the empiric management of CAP in inpatienst and outpatients. The present study conducted to find out the effectiveness of Levofloxacin in CAP among Bangladeshi Population. Total 50 Patients aged more than 18 years, diagnosed pneumonia based upon clinical features of respiratory tract infection and rediological changes, were included in this study. The study consists of four visits: first one for screening and enrollment. Second visit on day 2-4 during which patient on therapy, third visit 5-7 day after the last dose of the drug and fourth visit 28days after the last dose of the drug. The mean # SD of age of the respondents was 34.3# 19.1 years with a range of 18-100 years. Among the respondents 62.0% were male and 38.0% were female. Most of the respondents presented with fever (98.0%) and cough (100.0%) and chest pain was present in 66.0% cases. Ninety six percent respondents presented with productive cough and only 4.0% respondents with dry cough. Consolidation in left lower zone was the most common findings (32.0%) followed by consolidation in right mild zone (30.0%). Among the respondents 32.0% were treated with oral form and 68.0% were treated with injectable form of levofloxacin. About 92.0% were improved with the treatment. Levofloxacin monotherapy is well tolerated, cost-effective treatment for patients with CAP. Further large scale multi- centered study will help to strengthen this outcomeMedicine Today 2015 Vol.27(2): 9-13

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Background: Non-HDL cholesterol is a potential newer risk factor for cerebrovascular diseases (CVD). Objective: To explore the association of non-HDL cholesterol with cerebrovascular disease. Methods: This case control study was carried out in the Department of Biochemistry, BSMMU, Dhaka during the period of January to December 2007 to evaluate the association of non-HDL cholesterol with CVD in Bangladeshi population. A total number of 135 subjects of both sexes were grouped as Group-(CVD cases) and Group-II (Healthy controls). Group-I include 85 cases of which 59 were ischaemic cerebrovascular diseases (ICVD) and 26 were haemorrhagic cerebrovascular diseases (HCVD). By taking the history and doing clinical examination and laboratory investigations, diabetes mellitus, malignant disease, renal disease, liver disease and diuretic medication were excluded from study subjects. Serum non-HDL cholesterol was measured in all study subjects. Statistical analysis was performed by using SPSS for windows version 12.0. Mean values of the findings were compared between groups. One way ANOVA test and multiple comparison (Bonferroni't') test were used to see the level of significance. Results: Serum non-HDL cholesterol found significantly increased in CVD, ICVD and HCVD cases in comparison to control subjects. But ICVD and HCVD cases did not differ with respect to serum non-HDLcholesterol. Conclusion: The result shows that elevated non-HDL cholesterol is associated with CVD. Prospective study with large sample size is required to evaluate the elevated Non-HDL cholesterol as a risk factor of CVD.

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