Background: Ethnopharmacological studies have been framework of well established biological properties of medicinal plants. Most of these scientific studies are performed on individual plants but natural medicine treatments most often use mixtures of plants. The present study was undertaken to investigate the activity of the methanol/methylene chloride extract mixture from M. myristica, X. aethiopica and E. speciosa against Candida albicans isolates. Materials and Methods: The plant extract was prepared by maceration in methanol/methylene chloride. phytochemical analysis was performed by chemical reaction method. The broth microdilution method was used to evaluate the in vitro activity against ten isolates of C. albicans. The in vivo antifungal activity of X. aethiopica: M. myristica mixture (1:1) was evaluated using a Candida albicans induced gastrointestinal infection in a rat model. Results: The results of the phytochemical tests indicate that alkaloids and triterpenes were present in all extracts, other classes of chemicals being selectively present. Extracts and their mixtures displayed various degrees of antifungal activities. Xylopia aethiopica: M. myristica mixture (1:1) with MIC values ranging from 32-256 µg mLG 1 was found to have the best antifungal activity. This mixture at 200 and 400 mg kgG 1 b.wt. were able to progressively and significantly reduce the fungal load in the faeces of the infected rats within the treatment period. Conclusion: The results of this study provide an important basis for the use of methanol/methylene chloride extract mixture from M. myristica and X. aethiopica to control infectious diseases caused by C. albicans. Further studies need to be carried out as to establish the role of E. speciosa in the mixture.