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Objective: Vitiligo is a common depigmenting disorder with significant psychosocial consequences. Vitiligo has been associated with psychological disorders such as depression, low self-esteem, anxiety, and sexual dysfunction (SD). In recent years, there is an increase in the number of studies looking into the impact of vitiligo on sexual functions. This systematic review investigates the assessment and prevalence of SD in vitiligo patients. Materials and methods: We carried out a systematic search for observational studies on the prevalence of SD in vitiligo patients. The Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines were used to prepare this systematic review. We searched PubMed, Scopus, Google Scholar, and the Cochrane Library databases. Results: We observed 308 studies for screening. Finally, 12 studies that meet the eligibility criteria were included in this study. The prevalence of SD ranged from 2.7 to 82.0%. Most of the studies used the dermatology life quality index (DLQI) to assess SD. Our findings also show that vitiligo patients were more probably experience symptoms of depression and anxiety, one of the risk factors for SD. Conclusion: Psychological comorbidities are related to a high risk of SD in vitiligo patients. Further prospective longitudinal studies are required to investigate the causal factors for SD in vitiligo patients

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Bipolar disorder (BD) is a mood disorder where moods can fluctuate from depression to elevated moods referred to as mania. BD is currently divided into three types. All three types involve clear changes in mood, energy, and activity levels. BD-I is the most severe disorder and symptoms of mania can be so severe that they can require psychiatric hospitalization. BD-II has the same symptoms as BD-I; however, it was described as hypomania because they are less severe than in pure mania. Cyclothymia, also known as a cyclothymic disorder, is a minor mood disorder characterized by fluctuating low-level depressive symptoms and periods of mild mania, similar to BD-II. Mood stabilizers and second-generation antipsychotics are first-line for treating and maintaining a stable mood. This study related to a case report on slurred speech and tremors induced by antipsychotics in a patient suffering from BD.

Alagille syndrome is a rare, chromosome dominant inherited complex disorder affecting varying organs like the liver, heart, kidneys,  skeleton, and brain. lt invariably happens because of Notch signaling pathway defects, primarily as a result of JAG1 mutation (ALGS type 1), but it conjointly occurs seldom because of neurogenic locus notch homolog protein (NOTCH2) mutation (ALGS type 2). The symptoms and severity of Alagille syndrome can vary widely, often in the same family, from person to person. Some people may have mild forms, while others may have more severe forms. Blocking of bile flow from the liver (cholestasis), yellowish discoloration of the skin and mucosal membranes (jaundice), low body weight, and extreme itching (pruritis) are the common symptoms, which often occur within the first three months of life. In this current study, we tend to report a case of 14 years old female child who was hospitalized with characteristic facial features like a broad forehead, yellowish discoloration of sclera and skin, posterior embryotoxon, intense itching, dry, coarse skin, mild splenomegaly, mild hepatomegaly. She conjointly had a history of progressive neonatal jaundice with prominent skin lesions and edema. Therefore our study emphasizes and focuses mainly on understanding and identification of distinct features associated with this syndrome to aid better management in all cases.