Background: Urolithiasis is a chronic disease of mankind, which has enormous public health importance and it accounts for a substantial economic burden on our society. Hence, it becomes all the more important to formulate cheaper and easier means for treating this condition. The past few years have seen a number of drugs being introduced and successfully used in the medical expulsion therapy of small, uncomplicated ureteral calculi, with each drug claiming to provide better results than the others. Ours is perhaps the first study which has compared the efficacy of tamsulosin and silodosin in the medical expulsion therapy for ureteral calculi.
Aims:To compare the efficacy of tamsulosin (0.4mg) vs silodosin (8mg), both in terms of the stone expulsion rate and the time to stone expulsion.
Settings and Design:A prospective and a randomized controlled study was conducted in the Department of Urology, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India.
Material and Methods:From February to August 2012, 100 patients who were between the age group of 18-50 years, who had unilateral, uncomplicated middle or lower ureteral stones = 1cm were enrolled and they were divided into two groups. Group 1 received tamsulosin (0.4mg) daily, whereas Group 2 received silodosin (8mg) daily for a maximum period of 4 weeks. The patients were followed up weekly or biweekly with imaging studies. The primary endpoint was the stone expulsion rate and the secondary endpoints were the stone expulsion time, the rate of the interventions and the side effects.
Statistical Analysis:The statistical analysis was performed by using the Student's 't'-test and the Chi-squared test. A p value of < 0.05 was considered to be statistically significant. The SPSS-16 software was used for the statistical analysis of the data.Results: A spontaneous stone expulsion was observed in 58% of the patients in group 1 and in 82% of the patients in Group 2, which was statistically significant. There was also a significant difference between the groups with regards to the mean stone expulsion time. A lower analgesic use was found in Group 2.
Conclusion:In our study, silodosin was found to be clinically superior to tamsulosin, both in terms of the stone expulsion rate and the stone expulsion time.
Abstract:The reported incidence of male epispadias is 1 in 1,17,000 male births. The majority of cases go unseen in surgeons' life because of uncommon existence of this anomaly. We present our experience using the modified Cantwell-Ransley technique; particularly focusing on postoperative anatomical and functional outcomes. Between 2011 and 2013, two boys having primary penopubic epispadias with the spraying of urinary stream underwent one stage surgical reconstruction. Cavernocavernostomy was performed in all cases as a part of a procedure to correct dorsal curvature and for penile lengthening, but none of them required bladder neck procedure. At 3 rd and 6 th month follow-up period both of them found to have significant step forward subjective and objective outcomes. The cosmetic appearance of the phallus was not satisfactory in one case and it is because post-operatively the patient developed necrotic patches over the glans and neourethral skin that healed with fibrosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.