In this study we described the production of curcumin (CUR) loaded L-tyrosine (Tyr coated Fe 3 O 4 magnetic nanoparticles. CUR loaded Tyr modified Fe 3 O 4 nanoparticles (F@Tyr@CUR NPs) were analyzed by transmission electron microscopy, fourier transform infrared spectroscopy, thermo gravimetric analysis, vibrating sample magnetometer, X-ray diffraction and dynamic light scattering techniques. The dynamic light scattering results showed that the ζ-potential of F@Tyr@CUR NPs was about −15.4 mV. Also, the internal average size was about 25.81 ± 3.31 (mean ± SD (n = 30)) nm. The drug loading and encapsulation efficiency were 8.87 ± 0.09% and 35.21 ± 0.41%, respectively. In addition, hemolysis test on human red blood cells were conducted to determine the hemocompatibility of F@Tyr@CUR NPs. Next, MTT assays on HEK-293 were conducted to determine the toxicity of F@Tyr@CUR NPs.Lastly, the potential anticancer effect of F@Tyr@CUR NPs was considered on MCF-7 cancer cell line. The outcomes indicated that these F@Tyr@CUR NPs are appropriate for delivery of CUR anticancer drug. Also, the MRI training established the effectiveness of Fe 3 O 4 magnetic nanoparticles as contrast agent for the revealing of tumor as evidenced from the phantom images as well as higher T 2 relaxivity.

No abstract

No abstract