Background: Male infertility is defined as an inability to impregnate a fertile female; it is a widespread problem which is usually caused by some male factors such as low quantity and quality of sperm, specifically oligospermia and azoospermia.Objective: This study aimed to evaluate the bio-positive effects of low power density Wi-Fi radiation on the reproductive system of infertile and healthy mice.Materials and Methods: Thirty adult male Balb/c mice were randomly divided into 5 groups. Groups oligospermic-sham (OS), oligospermic-exposure 1 (OE1) and oligospermic-exposure 2 (OE2) received Busulfan, 10 mg/kg, intraperitoneally, but the control-sham (CS) and control-exposure (CE) groups left without Busulfan therapy. Groups CE, OE1 and OE2 were exposed to 2.4 GHz Wi-Fi radiation while, the CS and OS were sham exposed to Wi-Fi radiation without energizing the Wi-Fi router. The right and left testes and right epididymis were dissected out and histopathological, histomorphologic changes and the quality of the sperms were analyzed.Results: Low power density Wi-Fi radiation significantly increased sperm concentration in the CE group compared to that in CS, while enhancement of spermatid cells was not significant. Sperm concentration in OE2 was more than that in OE1 as the spermatid cells enhanced.Conclusion: Findings revealed that radiation hormesis induced by low power density Wi-Fi radiation have biological beneficial effects on mouse sperm concentration and sperm histomorphometric parameters.

Cell therapy using stem cell transplantation against cerebral ischemia has been reported. However, it remains controversial regarding the optimal time for cell transplantation and the transplantation route. Rat models of cerebral ischemia were established by occlusion of the middle cerebral artery. At 1, 12 hours, 1, 3, 5 and 7 days after cerebral ischemia, bone marrow mesenchymal stem cells were injected via the tail vein. At 28 days after cerebral ischemia, rat neurological function was evaluated using a 6-point grading scale and the pathological change of ischemic cerebral tissue was observed by hematoxylin-eosin staining. Under the fluorescence microscope, the migration of bone marrow mesenchymal stem cells was examined by PKH labeling. Caspase-3 activity was measured using spectrophotometry. The optimal neurological function recovery, lowest degree of ischemic cerebral damage, greatest number of bone marrow mesenchymal stem cells migrating to peri-ischemic area, and lowest caspase-3 activity in the ischemic cerebral tissue were observed in rats that underwent bone marrow mesenchymal stem cell transplantation at 12 hours after cerebral ischemia. These findings suggest that 12 hours after cerebral ischemia is the optimal time for tail vein injection of bone marrow mesenchymal stem cell transplantation against cerebral ischemia, and the strongest neuroprotective effect of this cell therapy appears at this time.

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