Abstract-It is becoming increasingly difficult to ignore the role of PowerPoint presentation on reading comprehension of deaf and hard of hearing (D/HH) students in schools. Based on different studies, PowerPoint, a common multimedia tool, has a crucial role in teaching and learning through providing a suitable understanding of the text and motivating students. The present study aimed to examine the predictive effects of PowerPoint presentations on reading comprehension of D/HH students. As reported in the literature, reading levels of deaf high school students are equal to those of fourth grade hearing students. Therefore, a visual computer-mediated approach was implemented to monitor the reading comprehension progress of 20 D/HH students in Iranian high schools. The reading comprehension of the experimental and control groups were compared by conducting the Stanford Achievement Test and applying paired t-tests. Our findings indicated a significant difference between the mean reading comprehension scores of the two groups.