Background: Malnutrition and inflammation have significant roles in chronic kidney disease (CKD), which causes cardiovascular mortality and morbidity. Objective: To evaluate the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as an inflammatory marker among CKD patients and their association with the nutritional status of the patients. Patients and Methods: A case-control study included 60 adult patients' non-dialysis CKD stage G3-5, from Ain Shams University Hospitals, and 30 healthy volunteers as a control group. Anthropometric measurements include body mass index, mid-arm circumference, triceps skin fold thickness, mid-arm muscle circumference (MAMC), and modified subjective global assessment (m-SGA). Laboratory parameters include complete blood count, NLR and PLR, hs-CRP, routine blood chemistry, and urinary albumin/creatinine ratio. Results: The mean of NLR in patients' group was significantly higher compared to healthy subjects. The mean of PLR in patients' group was higher than the control group, but with no statistically significant difference. Both ratios PLR and NLR were positively correlated to high hs-CRP in patients' group. The mean of hs-CRP among CKD patients was significantly higher than that in the control group. There was a significant correlation of NLR with MAMC in patients' group. But there was no statistically significant correlation between m-SGA score and NLR, PLR, or hs-CRP among patients' group. Conclusions: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio can be used as inflammatory markers in chronic kidney disease patients with malnutrition.