In the central laboratory of a hospital belonging to Diyala Health Governorate, to isolate and diagnoses Streptococcus mutans bacteria form dental caries infections, to detect the ability of isolate to biofilm formation, the sensitivity of isolates to antibiotics, and effect of plant extracts for Green tea and Capsicum annuum on the growth of the bacteria. The results showed that 68 Isolates belonged to Oral Streptococci were identify from 150 samples taken from dental caries infections, 20 isolates (13.3%) of S. mutans bacteria were obtained. The ability of isolate to form of biofilms by (80%), the isolates varied in their sensitivity to antibiotic, Where the percentages of sensitivity for Tetracycline (70%), Erythromycin (65%), Streptomycin (60%), Ciprofloxacin (50%), whereas resistance to antibiotics Amoxicillin, Ampicillin, Cefepime, Optochin (100%). The value of Minimum Inhibitory Concretion (MIC) of Tetracycline ranging from (256 -1024) micrograms \ ml , Erythromycin ranged from (64 -1024) micrograms \ ml. The inhibition zone of chili pepper and Green tea extracts for test isolates were (30)mm and (27) mm respectively, the comparison of inhibitory effect between plant extract and antibiotics the results indicate that the extracts of chili pepper and green tea have higher inhibitory effect than antibiotics against S.mutans Bacteria .This refers to the possibility of benefiting from those extracts in the manufacture of an alternative treatment, to minimizing the risks of resistance of bacterial as well as reduction the side effects that may be result from the use of s antibiotics , in addition, advantages such plants are easy to get and cheaply priced.