Periorbital hyperpigmentation (also recognized as periorbital melanosis, dark eye circles, and infraorbital darkness) is public cosmetic skin disorder with relative darkness of the periorbital. This condition is affected both sexes, they get worse by aging so it makes people look tired and older so it has a negative effect on the quality of life, particularly in women. 1 Many exogenous and endogenous reasons are overly involved in the pathogenesis of periorbital dark circles, containing genetics or heredity, facial structure, hyperpigmentation secondary to allergic and atopic contact dermatitis, troubled sleeping, smoking, alcohol drinking, and sun exposure can play a role in the development of these dark circles. 2 Several treatments are recommended for periorbital hyperpigmentation. However, there are

Fibroblasts are mesenchymal cells, which play an important role in epithelial-mesenchymal reactions. These cells also play a key role in epidermal proliferation and differentiation and cellular matrix formation through secretion of different growth factors and cytokines. Cell therapy is a new treatment for skin diseases. In fact, conditions, such as burns, diabetic wounds, scars, and aging skin, have been treated with these cells. In cell therapy, samples obtained from the patient's skin are isolated and cultured; then, the cells are injected into damaged tissues. In recent years, several clinical trials have been conducted in this area, and numerous studies have been published. In this review, we aimed to investigate the biology and function of these cells in the treatment of skin diseases.

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