PurposeThis study was taken up at this centre to look into the various causes of recurrence, clinicopathological profile and final outcomes in recurrent OSSN. MethodologyA prospective cohort study was conducted and total 18 patients were recruited. All patients were subjected to detailed history, comprehensive eye examination and imaging studies. A treatment plan was formulated based on the size and extent of the lesion. Primary outcome measures were resolution/regression of tumor, recurrence of the lesion and incidence of complication associated with each treatment modality.ResultsThe common cause of recurrence in our study was misdiagnosis of the lesion as in 15 cases it was diagnosed as pterygium and in 03 cases it was actinic keratosis. Excision Biopsy with adjunctive cryotherapy was the preferred treatment modality followed by topical interferon @ 2b drop in our study. We could achieve good outcomes in terms of complete regression of the tumor in 15 cases. The complication associated with this treatment was minimal in our study as few patient develop redness and irritation which got subsided after application of topical lubricants. There was no recurrence of the lesion even after 06 months of follow up in all 18 cases.ConclusionRecurrence can be mitigated in all cases of OSSN if they are diagnosed on time with institution of appropriate treatment modality. Regular follow- up is required to assess the response to treatment and change over to new treatment plan in cases with inadequate response to curb the incidence of recurrence in OSSN.