The polycystic ovarian syndrome is a hormonal disorder affecting 7% of the reproductive age of women. Women with PCOS have an irregular menstrual cycle, excess androgen, anovulation, hirsutism, and infertility. As per Ayurveda, this type of clinical feature is found in Pushpaghni Jataharini and Nashtartava. The present study provides information about some herbal plants, active plant constituents, and some formulations clinically tested in animal models that induce PCOS and humans suffering from PCOS. Aim: A clinical study of etiopathogenesis of obese (Sthula) PCOS and its management by Medoharguggula. Methodology: The two sections have made for a better understanding of the aim and objectives of the present study. The study was conducted on 30 patients. The drug Medoharguggula was given in Vati form with the dosage of 500 mg thrice a day with lukewarm water. This study was conducted at Bharati Ayurveda hospital during 2020-2022. It was a randomized, open clinical trial study. Results: A total of 35 patients were evaluated in this study. Out of which five discontinued the treatment, and 30 patients completed it. Conclusions: The herbal contents of the drug were found effective in reducing weight. It was not found effective in reducing BMI, hirsutism, acanthosis nigricans and weight reduction. Also, the menstrual cycle interval was found to be regular or at the interval of 45 days in 80% of the patients.

PCOS is the most common endocrine condition in reproductive-aged women. The word “Syndrome” is used to describe PCOD because, it is a complex manifestation involving many factors and organs. It is characterized by reproductive, endocrine, metabolic and physiological features. The presence of polycystic ovaries is an important diagnostic criterion for PCOS. This syndrome can also be associated with metabolic issues including obesity, insulin resistance, hyperinsulinemia. Recently, there has been an increase in inter-est in the field of PCOS research. It is categorized as a chronic disease with treatments that only address symptoms, the condition is terrifying to most because of its painful and uncomfortable side effects, ad-verse impact on fertility, and high risk of complications. PCOS in Ayurveda is correlated with Ar-tavakshaya. It needs early diagnosis and long-term management for avoiding long term complications. This article aims to provide a balanced review of the latest advances and current limitations in our knowledge about PCOS while also providing a few clear and simple principles, based on current evidence-based clini-cal guidelines, for the proper study of pathogenesis of PCOS, also by looking at the findings of modern medicine we are correlate here the exhibiting features of the disease with the dominate Dosha responsible for the disorder.