Alzheimer's disease (AD) is a neurological ailment that primarily affects the elderly and necessitates an efficient treatment regimen backed up by extensive care. Despite advancement in the in vivo imaging techniques focussing on early diagnosis of reliable biomarkers using novel magnetic resonance imaging (MRI) and positron emission topography (PET) scans, AD remains largely unexplained and effective preventative and treatment strategies are still lacking. Consequently, research groups are constantly attempting to improve its early detection, using both invasive and non‐invasive techniques with established core markers like Aβ and Tau (t‐tau and p‐tau) proteins. Unfortunately, African American and other black races are facing an increasing burden of closely associated risk factors, and only a few attempts have been made to find effective complementary and alternative therapies for AD cure and management. A greater epidemiology and natural product research are required to deal with the concurrent rise of dementia among quickly ageing African population, which so far have largely been ignored in addition to a disparity in the AD risk factors. We have tried to bring attention to the issue by reviewing up on this predisposition while generating a perspective on how race may affect AD risk and expression. This article also puts emphasis on finding new research leads from African phytodiversity while presenting several of the important species along with their biological agents found helpful in dementia related symptoms.

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Medicinal plants are an excellent source of new therapeutic drugs because of their phytochemical constituents. Arctium lappa L. (common name-burdock) is a perennial medicinal herb commonly found in China, Japan, Korea traditionally used as promising health supplement. promising health supplement. Major active constituent of A. lappa L. seeds are arctigenin which exhibits pharmacological potential such as anti-inflammatory, anticancer, antimicrobial and hepatoprotective properties. The purpose of this study is to provide an up-to-date evaluation of the literature on the pharmacological activities of Arctigenin from Articum lappa L. Literature is collected from Google scholar, Science Direct, Research Gate, PubMed, Google, and SciFinder databases published between 2012 and 2021 (Jan). Keywords used to retrieve the data are pharmacological profile, arctigenin, and Arctium lappa L. The antioxidant, anti-inflammatory, anti-tumor, hepatoprotective, renoprotective, neuroprotective, and CNS depressant properties of arctigenin demonstrated its pharmacological significance among traditional science According to different research, arctigenin is effective in the treatment of a variety of chronic disorders, including cancer (stomach, lungs, liver, and colon) and inflammatory diseases (rashes, and other skin conditions.). Future experiments based on the mechanism pathway responsible for the protective role of arctigenin's will help the scientist to uncover its health benefits.

Alzheimer’s disease (AD) is a neurological ailment that primarily affects the elderly and necessitates an efficient treatment regimen backed up by extensive care. At the moment, treatment for AD is still in its early stages and is often regarded as insufficient by the medical community, with synthetic medications commonly used that have several side-effects. Consequently, research groups are constantly attempting to improve its early detection, particularly through biomarkers, as well as to find effective complementary and alternative therapies for its management. Medicinal plants have long been used as a source of biomolecules as well as complementary medicines. Africa ranks second among biodiversity hotspots in the world due to geographical variances in distribution and vegetation zones. In comparison to nations like India and China, it is believed that much of its biodiversity remains unexplored, and that it may be home to many previously unknown medicinal plants. This calls for more research on African medicinal herbs and finding a key remedy to treat and manage AD. The major scientific biomedical literature databases viz. PubMed, Scifinder, The Lens, Google Scholar, etc. were accessed and the information available till September 2022 was reviewed, with a focus on documenting such herbs along with their active biomolecules that could lead to noble drugs against AD. Also, the review has looked up on the risk factors prevalent among African communities to have a perspective on how race may affect AD risk and expression.