Gonadotropin theory of ovarian cancerOvarian cancer is the most lethal gynecological malignancy. Although epithelial ovarian carcinomas account for approximately 90% of all human ovarian cancers, the etiology of this disease is poorly understood. Fathalla proposed the 'incessant ovulation theory' in 1971, suggesting that continuous ovulation, associated with successive rounds of surface rupture and repair, increases the chance of accumulating genetic aberrations and therefore malignant transformation [1]. The hypothesis is supported by substantive epidemiological data. For example, one case-control study of 150 ovarian cancer patients under the age of 50 years demonstrated that the risk of ovarian cancer decreased with increasing numbers of live births, increasing numbers