Cocaine is an addictive drug. Thousands of years ago it made by South America from leaves of coca plant. It is also known as a coke. It appears as a fine white crystalline powder. Surgeons used it to block pain, before the development of synthetic local aesthetic. There is no pharmacological treatment for that addiction. It impact on a genetic factor and brain. It also consists as a brain disease, which effects directly on a neuropath ways of brain and it modified the various enviourment factors like; epigenetic, hinges, mentality, social influences, etc. its addiction can developed quickly even after trying a few times. These drugs quickly affected health like; psychological effects, physical effects and mentally effects or any other diseases. All stimulants function as an extracellular concentration of dopamine, norpinephirine and serotonin which can induce symptoms such; paranoia, panic, hallucination, aggression, irritability, anxiety, depression, poor judgement, repeated or aberrant behaviour. Some physical effects of this medication are harmful weight loss; raise heart rate, nausea, abdomen pain, headaches, chest discomfort, heart arrhythmia, heart attack, seizure, stroke and many more such ailments. These drugs can block the transport of these neurotransmitters.

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