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To cite this article: Fatmah M. Alshammari, Sonia M. Reda & Magdy M. Ghannam (2017) Potential effects of gamma irradiation on the stability and therapeutic activity of anticancer drug, a b s t r a c t Cancer therapy has progressed dramatically in recent years. In order to decrease the dose and side effects of the anticancer drug, the therapeutic options for patients with cancer include increasingly complex combinations of chemotherapy and radiotherapy. This combination may cause overlapping interaction between the two types of treatment and affect the stability of the anticancer drug. In this study, the effect of gamma irradiation on the stability and therapeutic activity of one anticancer drug (Doxorubicin) was studied. For this purpose, doxorubicin drug characterized by two methods, at first, in-vitro study, before and after drug irradiation with different doses of gamma rays (2, 5, 20, 100 GY) which achieved through measuring the dielectric relaxation and absorption spectrum of drug solution. Secondly, in-vivo studies, where the unirradiated and the drug, which later exposed to gamma rays, were injected respectively into 6 groups of mice (3 mice in each group). The dielectric relaxation and absorption spectrum were studded for hemoglobin of the injected mice. The results for the in-vitro study indicate that the values of dielectric parameters show unnoticeable change for drug molecules before and after irradiation as compared with the control. The results for in-vivo study indicated an increase in the values of relaxation time and Cole-Cole parameter, that may as a result of changes in the conformational structure in hemoglobin molecules which may affect their properties and hence RBC's physiological functions. The absorption spectra of hemoglobin molecules show an increase in the amplitude of the characteristic bands with irradiation dose indicate an increase of the oxygen binding capacity with hemoglobin. It was concluded that combination between the drugs and gamma irradiation can be used as a powerful conjunction that may give us the benefit chemo and radiotherapy treatment.

1 Phys ics De part ment, Fac ulty of Sci ence, Zagazig Uni ver sity, Zagazig, Egypt 2 Phys ics De part ment, Col lege of Sci ence, Jouf Uni ver sity, Sakaka, Saudi Ara bia 3 Zagazig Higher In sti tute for En gi neer ing and Tech nol ogy, Zagazig, Egypt 4 Nu clear and Ra dio log i cal Reg u la tory Au thor ity, Cairo, Egypt Sci en tific pa per https://doi.org/10.2298/NTRP190705002RThe pres ent work stud ies the ef fect of in tro duc ing MOX fuel on West ing house AP1000 neutronic pa ram e ters. The neutronic cal cu la tions were per formed by us ing the MCNP6 code with the ENDF/B-VII.1 li brary and the new re lease of the ENDF/B-VIII, the AP1000 core with three 235 U en rich ment zones (2.35 %, 3.40 %, and 4.45 %). The ob tained re sults showed that the sim u lated model for the AP1000 core sat is fies the op ti mi za tion cri te ria as a West inghouse ref er ence. The re sults which in cluded: ef fec tive mul ti pli ca tion fac tor, k eff , de layed neutron frac tion, b eff , ex cess re ac tiv ity, r ex , shut down mar gin, tem per a ture re ac tiv ity co ef fi cients, whole core de ple tion, neu tron flux, power peak ing fac tor and core power den sity, were cal culated and com pared with the avail able pub lished re sults. The k eff in the cold zero power was found to be 1.20495 and 1.20247 with the ENDF/B-VII.1 and the ENDF/B-VIII li brar ies, re spec tively, which matches the value of 1.205 pre sented in the AP1000 De sign Con trol Docu ment for the UO 2 fuel core. On the other hand, k eff in the cold zero power was found to be 1.19988 and 1.19860 for MOX core with the ENDF/B-VII.1 and the ENDF/B-VIII li braries, re spec tively, which show good re cep tion and con firm the safety of the de sign and ef fi cient mod el ing of AP1000 re ac tor core.