Mindfulness-based interventions are increasingly popular, and many practitioners maintain the practice for several years. Experienced mindfulness practitioners (N=22) explained how they perceived the outcomes, the process, and the particularities of their experience. Semi-structured interviews were analyzed leading to the identification of four distinct moments in mindfulness practice: introduction to mindfulness and life immersion, mindfulness skill and life discomfort, mindfulness living and life connection, and mindfulness and life engagement. Practitioners report perceived efficacy and flexibility of behavioral, cognitive, and emotional processes as a consequence of long-term mindfulness practice. Changes in the differentiation of the self, in self/other perspectives, in equanimity, in the locus of control, and in choice patterns seem to be central mechanisms to receive research attention.