General procedure for the synthesis of 1-acetoxy-1H-indene-2-carboxylic acid alkyl ester 2a-eTo a mixture of alcohol 1 (5 mmoles), acetic anhydride (25 mmoles) in 40 mL of anhydrous ether cooled at 0 °C under stirring in nitrogen atmosphere, was added a drop of concentrated sulfuric acid. After completion of the reaction, the mixture was hydrolyzed with ice water and extracted with ether (3x20 mL). The organic layers were washed successively with sodium hydroxide solution (1.5M) and brine until neutral pH then dried over MgSO 4 and concentrated in vacuo. After evaporating of the solvent, The residue obtained was purified by silica gel column chromatography (AcOEt:Hexane, 7/3). The spectral ( 1 H and 13 C NMR and HRMS) data of the unknown compounds 2a-e are given below.Selected Data 1-Acetoxy-1H-indene-2-carboxylic acid methyl ester 2a

An elegant one-pot synthesis of new indenols 2 was successfully carried out, starting from 1-hydroxy-1H-indene-2-carboxylic acid 1. Thus, esterification of acid 1 with aliphatic alcohols in toluene at reflux and a catalytic amount of para-toluenesulfonic acid afforded the corresponding alkyl esters 2 in moderate to good yields. This classical esterification process enables an efficient entry to a variety of new indenol-based molecular models 2, which could be adapted to a range of drug candidates. All the synthesized compounds 2a-e were subjected to the preliminary evaluation for their potential anti-oxidant and anti-bacterial activities. The assessment of radical scavenging capacity of the compounds 2a-e towards the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) was measured and these compounds were found to scavenge DPPH free radical efficiently. Moreover, the in vitro antibacterial activity of derivatives 2a-e has been tested against a panel of pathogenic agents to show potent activity against all sensitive and resistant ones.

We present herein an efficient and rapid method for the synthesis of N,1‐dialkyl‐4‐(2‐hydroxyethyl)‐5‐oxopyrrolidine‐3‐carboxamides based on the conversion of γ‐lactone to γ‐lactam via the conjugate addition of primary amines to an ethyl α‐functionalized acrylate followed by intramolecular cyclization.

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A convenient protocol for the synthesis of highly functionalized indenes 4 has been developed. The coupling reaction of bicyclic Baylis-Hillman acetate 2 with nitroalkane salts in basic conditions led to the corresponding substituted indenes in good yields and high purity.