Introduction In 2017, a quadrivalent inactivated split-virion influenza vaccine (QIV; Vaxigrip Tetra ® , Sanofi) was licensed in South Korea for active immunization against influenza A and influenza B viruses in individuals aged 3 years or older, which was subsequently extended to individuals aged 6 months or older in 2018. Post-marketing surveillance trials are mandatory in South Korea to retain drug licensure. Here, we assessed the safety of QIV in routine clinical practice in South Korea. Methods This was an open, multicenter, observational, active safety surveillance study conducted between 20 June 2017 and 19 June 2021 at 10 study sites in South Korea in individuals aged 3 years or older who received a single dose of QIV during a routine healthcare visit. The participants or their legally acceptable representatives were instructed to record any adverse reactions (solicited events) and unsolicited non-serious adverse events (AE) in diary cards, and notify study investigators in case of serious adverse events (SAE). Results Overall, 663 participants were included in this study. There were no AEs leading to study termination, and no SAEs reported. Injection site pain (278 [41.9%]) was the most frequent solicited injection site reaction, with myalgia (250 [37.7%]) and malaise (236 [35.6%]) the most frequent solicited systemic reactions. Grade 3 solicited injection site and systemic reactions were reported by 8 (1.2%) and 13 (2.0%) participants, respectively; most participants with solicited reactions recovered without the need for further action. Overall, 39 (5.9%) participants experienced 49 unsolicited non-serious AEs with the most frequently reported being nasopharyngitis (19 [2.9%]). Grade 3 unsolicited non-serious adverse events were reported in 1 (0.2%) participant. None of the unsolicited non-serious AEs were considered to be related to QIV. Conclusion This post-marketing surveillance study confirms that QIV is well tolerated and has an acceptable safety profile in routine practice in South Korea. No unexpected safety concerns were identified. Trial Registration ClinicalTrials.gov identifier NCT05406180.

This study examined the chemical characteristics and the microstructure of Goryeo whiteware which was excavated in the kiln site Yucheon-ri, Gangwon-do, the southern part of South Korea. this area is considered to be used in the middle of the time of Goryeo Dynasty. We analyzed the chemical characteristics comparing Goryeo Whiteware from Seo-ri, Jungam-ri, Bangsan-dong and The temple site of Beopcheon. Based on the analysis, we confirmed the properties of raw material for making pottery. It is featured that body composition of Goryeo Whiteware from Yucheon-ri contains high silica and low solvent. However, the contents of the glaze are vice versa. Goryeo whiteware tends to contain larger part of oxide than that of titanium oxide, which applies to Goryeo Celadon. the whitewares during the early days of Goryeo Dynasty varies in components depending on kilns, whereas it does not mean that chronological changes happened in components. The whiteware shards from Yuchoen-ri have a similar aspect. The whiteware shard from the temple of Beopchen differ in composition, Thus they are estimated to have been produces and shipped from various sites. In conclusion, we judged that the component difference among Goryeo whitewares stems from production environment and origin of raw materials rather than chronological changers.

permutations for SRF and for SRF-MRTF complexes. The power of this approach allows us to investigate all possible consensus (64 possible sequences) and single mutant (768 possible sequences) using traditional EMSA-based approaches. Additionally we aim to identify cooperativity effects between MRTF and SRF in a sequence dependent fashion. These sequence sets (consensus and single mutants) account for up to 70% of all naturally occurring murine CArG boxes and understanding this energy landscape will facilitate the development of thermodynamic models for understanding the gene specific, mechanically driven behavior of MRTF/SRF across the genome. These models may be useful in understanding a variety of soft-tissue fibrotic conditions and other pathological processes, like metastasis, that appear MRTF/SRF responsive.