BackgroundGlomus tumors were first described by Wood in 1812 as painful subcutaneous tubercles. It is an uncommon benign neoplasm involving the glomus body, an apparatus that involves in thermoregulation of cutaneous microvasculature. Glomus tumor constitutes 1%-5% of all hand tumors. It usually occurs at the subungual region and more commonly in aged women. Its classical clinical triad consists of pain, tenderness and temperature intolerance, especially cold sensitivity. This study reviews 15 cases of glomus tumor which were analyzed according to its anatomic location, surgical approach and histologic findings.MethodsFifteen patients with subungual glomus tumors of the hand operated on between January 2006 and March 2013, were retrospectively reviewed. Patients were evaluated preoperatively with standard physical examination including ice cube test and Love's test. Diagnostic imaging consisted of ultrasonography, computed tomography, and magnetic resonance imaging. All procedures were performed with tourniquet control under local anesthesia. Eleven patients underwent excision using the transungual approach, 3 patients using the volar approach and 1 patient using the lateral subperiosteal approach.ResultsTotal of 15 cases were reviewed. 11 tumors were located in the nail bed, 3 in the volar pulp and 1 in the radial aspect of the finger tip. After complete excision, patients remained asymptomatic in the immediate postoperative period. In the long term follow up, patients exhibited excellent cosmetic results with no recurrence.ConclusionsAccurate diagnosis should be made by physical, radiologic and pathologic examinations. Preoperative localization and complete extirpation is essential in preventing recurrence and subsequent nail deformity.

Pancreas or islet transplantation is recommended for individuals with type 1 diabetes who present with frequent and severe hypoglycemia and/or severe glycemic lability, despite efforts to optimize glycemic control [1]. For these patients, pancreas or islet transplantation has led to successful treatment of these problems [2][3][4]. Pancreas and islet transplantations have previously been performed in Korea [5,6].Clinicians can judge whether patients with type 1 diabetes have problems with glycemic lability and/or severe hypoglycemia, but it is difficult to quantify the glycemic lability and hypoglycemia.Attempts have been made to quantify both hypoglycemia and glycemic lability to allow for betweenAssessment of glycemic lability and severity of hypoglycemia in Korean patients with type 1 diabetes abstract. Few studies have focused on the quantification of glycemic lability and hypoglycemic events in Asian patients with type 1 diabetes; therefore, we conducted a study to assess glycemic lability and the severity of hypoglycemia in type 1 diabetic patients in Korea. A total of 124 type 1 diabetic patients were enrolled. Several glycemic lability indexes and hypoglycemic indexes were calculated using four-week self-monitoring of blood glucose (SMBG) data. Due to the dependence of the lability index (LI) on the frequency of glucose measurements, we generated a modified LI by dividing by the number of SMBG measurements per day for a given patient. The numbers of patients in our study with a composite hypoglycemic score ≥ 1,047 or LI ≥ 433 mmol/L 2 /h·week -1 , which was found in a previous study to indicate high risk of severe hypoglycemia or lability, were 0 (0%) and 44 (35%), respectively. Compared to previously reported hypoglycemia indexes, the low blood glucose index was lower in our study. However, the glycemic lability indexes were similar to those in previous studies, with the exception of the LI. The modified LI and the average daily risk range (ADRR) showed higher concordance with other glycemic lability indexes than did the LI or mean amplitude of glycemic excursions (MAGE). The results showed that the hypoglycemic indexes in this study population were lower than the results from Ryan et al. Furthermore, the ADRR or modified LI were better measures for high risk of severe lability than were the LI and MAGE.Key words: Glycemic lability, Type 1 diabetes mellitus, Hypoglycemia center comparison as well as to establish standards for pancreas or islet transplantation [7]. Several indexes have been proposed for glycemic lability and hypoglycemia. The most familiar assessment of glycemic lability is the standard deviation (SD) of the glucose profile [8]. However, the SD has limited capacity to identify the extremes of hyperglycemia or hypoglycemia and is affected by the mean glucose [9]. The mean amplitude of glycemic excursions (MAGE) and average daily risk range (ADRR) also measure glucose lability in diabetic patients [10,11]. The MAGE using continuous glucose monitoring is a well-known index of glycemic labil...

H. pylori eradication therapy is commonly associated with antibiotics-associated gastrointestinal abnormal responses, which may result in antibiotics intolerance and H. pylori eradication failure. Even though those symptoms are not so severe, we have to consider the gastrointestinal abnormal responses associated with H. pylori eradication, especially diarrhea.

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