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A novel series of copper-activatable drugs intended for use against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillinresistant S. aureus (MRSA) were synthesized, characterized, and tested against the MSSA strain Newman and the MRSA Lac strain (a USA300 strain), respectively. These drugs feature an NNSN structural motif, which enables the binding of copper. In the absence of copper, no activity against MSSA and MRSA at realistic drug concentrations was observed. Although none of the novel drug candidates exhibits a stereocenter, sub-micromolar activities against SA Newman and micromolar activities against SA Lac were observed in the presence, but not in the absence, of bioavailable copper.Copper influx is a component of cellular response to bacterial infections, which is often described as nutritional immunity.

Colleges and universities that can withstand the fallout of the COVID-19 crisis will need to redouble their efforts to engage students in the kinds of intellectual and social experiences that cannot be attained remotely or in isolation. Public humanities, which promotes collaboration, civic and community engagement, and inter-institutional alliances, can be one such reparative force for the reconstructed university. This essay describes the work of graduate student researchers in an interdisciplinary public humanities seminar at Emory University who partnered with a large regional theater on a project involving dramaturgy and audience engagement for a spring 2020 production of Lynn Nottage’s play Sweat (first performed in 2015). The graduate seminar and the project—both before and in the wake of the COVID-19 outbreak—offer a compelling model for critical humanistic pedagogy and research that counteracts the isolation and insularity exacerbated by the pandemic.

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