Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell transplantation. Although we have made substantial progress in understanding disease pathogenesis and the role of specific immune cell subsets, treatment options are still limited. To date, we lack a global understanding of the interplay between the different cellular players involved, in the affected tissues and at different stages of disease development and progression. In this review we summarize our current knowledge on pathogenic and protective mechanisms elicited by the major involved immune subsets, being T cells, B cells, NK cells and antigen presenting cells, as well as the microbiome, with a special focus on intercellular communication of these cell types via extracellular vesicles as up-and-coming fields in chronic Graft-versus-Host Disease research. Lastly, we discuss the importance of understanding systemic and local aberrant cell communication during disease for defining better biomarkers and therapeutic targets, eventually enabling the design of personalized treatment schemes.

The interwar years in Britain are regularly referred to by historians and literary commentators as the Golden Age of detective fiction (c. 1920–1940). This article focuses on the Collins imprint the Crime Club, established in 1930. It assesses the significance of this imprint in the context of the Golden Age, with a focus on its commercial animus, drawing on theories about class-based markets and the commercialization of print culture. The article examines the marketing methods used by the Crime Club to promote its titles, such as newsletters and card games, and takes into consideration the arguments of 1930s literary critics. It aims to show that detective fiction had a significant role in the commercialization of print culture during the 1930s and that its success heavily relied upon the support of a middle-class readership.

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