The DC results in a significant, immediate, and durable improvement of ICP associated with a normalization of cerebral blood flow velocities in most TBI patients with refractory intracranial hypertension.

Our results show a better agreement of prescribing practice with contraindications and cautions about LMWH prescription in patients at risk following the introduction of guidelines on LWMHs. However, these data only reflect LMWH utilisation in a French university hospital. In order to assess the impact of the guidelines more widely, other studies should be performed, including studies in ambulatory care settings.

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