Sequential detection is based on a recursive statistic and a threshold it must reach to report a change. In this paper, we consider the score‐based cumulative sum statistic and propose to evaluate the detection performance of some thresholds on simulated data. Three thresholds come from the literature: the Wald constant, the empirical constant, and the conditional empirical instantaneous threshold (the latter two are built by a simulation‐based procedure). Two new thresholds are built by a simulation‐based procedure: the first one is instantaneous, the second is a dynamical version of the previous one. The thresholds' performance measured by an estimation of the mean time between false alarm (MTBFA) and the average detection delay (ADD) are evaluated on independent and autocorrelated data for several scenario, according to the detection objective and the real change in the data. The simulations allow us to compare the difference between the thresholds' results and to see that their performances prove to be robust when a parameter of the prechange regime is misestimated or when the data independence assumption is violated. We found also that the conditional empirical threshold is the best at minimizing the detection delay while maintaining the given false alarm rate. However, on real data, we suggest to use the dynamic instantaneous threshold because it is the easiest to build for practical implementation.

Over the last few years, taking advantage of the linear kinetics of the tumor growth during the steady-state phase, tumor diameter-based rather than tumor volume-based models have been developed for the phenomenological modeling of tumor growth. In this study, we propose a new tumor diameter growth model characterizing early, late and steady-state treatment effects. Model parameters consist of growth rhythms, growth delays and time constants and are meaningful for biologists. Biological experiments provide in vivo longitudinal data. The latter are analyzed using a mixed effects model based on the new diameter growth function, to take into account inter-mouse variability and treatment factors. The relevance of the tumor growth mixed model is firstly assessed by analyzing the effects of three therapeutic strategies for cancer treatment (radiotherapy, concomitant radiochemotherapy and photodynamic therapy) administered on mice. Then, effects of the radiochemotherapy treatment duration are estimated within the mixed model. The results highlight the model suitability for analyzing therapeutic efficiency, comparing treatment responses and optimizing, when used in combination with optimal experiment design, anti-cancer treatment modalities.

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