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One of the key challenges that the pharmaceutical industry is trying to address is to maintain particle properties across the entire purification and isolation process. This research focuses on the effect of slurry properties, wash solvent, filtration and washing mechanisms on API agglomeration/granulation during the processes of downstream isolation and the impact on the physical properties of the product. In this investigation, each isolation step was analysed to identify factors that have the potential to affect the final product qualities using a multivariate statistical design of experiments approach.The factors which were most detrimental in increasing particle agglomeration, were found to be the particle size of the input material, the quantity and identity of wash solvent and the drying mode. Low boiling point aliphatic

Properties critical to the structure of apparel and apparel fabrics (thermal and moisture transfer, elasticity, and flexural rigidity), those related to performance (durability to abrasion, cleaning, and storage), and environmental effects have not been consistently addressed in the research on fabric sensors designed to interact with the human body. These fabric properties need to be acceptable for functionalized fabrics to be effectively used in apparel. Measures of performance such as electrical conductivity, impedance, and/or capacitance have been quantified. That the apparel/human body system involves continuous transient conditions needs to be taken into account when considering performance. This review highlights gaps concerning fabric-related aspects for functionalized apparel and includes information on increasing the inclusion of such aspects. A multidisciplinary approach including experts in chemistry, electronics, textiles, and standard test methods, and the intended end use is key to widespread development and adoption.

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Electrically conductive fabrics are achieved by functionalizing with treatments such as graphene; however, these change conventional fabric properties and the treatments are typically not durable. Encapsulation may provide a solution for this, and the present work aims to address these challenges. Next-to-skin wool and cotton knit fabrics functionalized using graphene ink were encapsulated with three poly(dimethylsiloxane)-based products. Properties known to be critical in a next-to-skin application were investigated (fabric structure, moisture transfer, electrical conductivity, exposure to transient ambient conditions, wash, abrasion, and storage). Wool and cotton fabrics performed similarly. Electrical conductivity was conferred with the graphene treatment but decreased with encapsulation. Wetting and high humidity/low temperature resulted in an increase in electrical conductivity, while decreases in electrical conductivity were evident with wash, abrasion, and storage. Each encapsulant mitigated effects of exposures but these effects differed slightly. Moisture transfer changed with graphene and encapsulants. As key performance properties of the wool and cotton fabrics following treatment with graphene and an encapsulant differed from their initial state, use as a patch integrated as part of an upper body apparel item would be acceptable.