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Purpose Joint instability is a common joint dysfunction and a cause of musculoskeletal disorder and pain after anterior cruciate ligament injury and osteoarthritis. The aim of this literature review is to review the existing evidence regarding the impacts of knee brace in persons with joint instability, or laxity after knee disease concerning physical and functional outcomes. Methods A systematic search was performed at MEDLINE, Central Register of Controlled Trials (CENTRAL), PubMed, and PEDro and Web of Science databases until April 2, 2022, with their language limited to English. Studies to be included were randomized controlled trials (RCTs), controlled clinical trials, and controlled experimental studies that included comparison of interventions and no interventions testing effectiveness of orthotics in joint instability symptom patients Results Total 250 studies were retrieved and 12 articles met the inclusion criteria. Beneficial effects of knee braces appear to vary with disease. Self-reported instability may be improved with orthotics, while its effects are unclear in an objective assessment of joint instability. However, improved subjective instability lead to improved physical function. Conclusion Our aim is to provide information to both healthcare professionals with updated and high-quality recommendations for the management of instability joint condition. It is concluded that orthotic therapy may have a certain effect on subjective evaluation in joint instability.

Introduction: Muscle weakness rotator cuff tear (RCT) after is the most important factor for physical function. However, the mechanism underlying muscle atrophy and treatment after rotator cuff injury remains to be elucidated. This study sought to systematically review published animal studies to explore effective treatment options for muscle weakness following human rotator cuff injury, focusing on fibro-adipogenic progenitors (FAPs). Materials and methods: MEDLINE, PubMed, and Embase were systematically searched for articles published in June 2022, using relevant keywords. Animal species, injury and repair types, study duration, and fatty degeneration parameters were summarized. Results: Of the 120 studies, 51 were secondarily evaluated for cell treatment of muscle weakness in rotator cuff injury. Finally, six studies examining the effects of FAPs on atrophy were selected for analysis. Six studies showed positive effects on the supraspinatus muscle following FAP (n = 3) or pluripotent stem cell (n = 3) injections. Conclusion: Following the review, we concluded that FAP might be effectively inhibit fatty degeneration after rotator cuff injury. However, mechanical stress also should required for prevention of muscle weakness in various article. Overall, there are few FAP injection reports for RCTs, and basic research should proceed in this direction.

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