Neonatal suppurative parotitis (NSP) is a very rare disease of the salivary glands, usually involving the parotids. It is mostly due to Staphylococcus aureus bacterial infection among patients with predisposing factors, and management mainly relies on hydration and intravenous antibiotics with an excellent prognosis. Herein, we present a case of an 11-day-old female baby who presented with left periauricular edema and tenderness associated with fever that was later diagnosed as NSP due to both non-typable beta-hemolytic streptococci and Escherichia coli. Antibiotics therapy (vancomycin and gentamicin) was started, and the patient recovered completely after nine days. The CAse REport (CARE) guidelines were followed for reporting our case. Our case reiterates the fact that NSP should be in the differential diagnosis of any neonate presenting with fever and parotid area swelling. Prompt diagnosis is necessary for early management with antibiotics and to avoid complications.