No abstract

The alkaloid extract of datura stramonium (rich of atropine, hyoscyamine, scopolamine) is used to evaluate its effect on the central nervous system in rats (locomotion, anxiety). The animals received the alkaloid extract of datura by intraperitoneal injection. However, after the injection a group of rats got an inhibitory treatment contain flavonoids extracted from Rosmarinus officinalis. At the dose of 50 mg/kg/body weight of the alkaloid extract, the female rats have shown a reduction of locomotor activity and an induction of an anxiogenic effect. In the other hand, the mixture of Datura stramonium and Rosmarinus officinalis showed a neuroprotective action with regard to the disorders induced by extracts of Datura stramonium.

The present study investigated the effect of Lepidium sativum L. on Memory and on Acetylcholinesterase (AChE) activity in different brain structures among cadmium-exposed rats. Animals were divided into three groups: Control group (T): received a distilled water orally, Cadmium group (Cd): received oral administration dose of Cadmium Chloride (CdCl2) at 10 mg/kg, Protective group (Cd/LS): received CdCl2 (10mg/kg) and the aqueous extract of Lepidium sativum L. (20mg/kg) orally. The Novel Object Recognition Memory Test is used to evaluate the short and long term memory. The measure of AchE activity is realized by Ellman’s method. The results showed that subchronic Cadmium Chloride intoxication at a dose of 10 mg/kg caused a neurobehavioral impairments including: A significant decrease in the index of recognition of short-term (p<0.01) and long-term memory (p <0.05) compared to the control group. In addition, this index increase in the group (Cd/LS) compared to the group intoxicated by CdCl2. A highly significant increase in the enzymatic activity of acetylcholinesterase in hippocampus, cerebellum, and cortex (p<0.001) is registered. These results indicate that the aqueous extract of Lepidium sativum L. may modulate the toxic effect induced by cadmium and consequently improve cognition.

Helicobacter pylori (H. Pylori) is the best example of the implication of chronical infection in carcinogenesis. The World Health Organization recognized it as a class I carcinogen since it triggers the progression of premalignant gastric lesions. The aim of this study is to define the prevalence of H. Pylori infection, related risk factors, and explore the histological features of the chronic gastritis. This is a retrospective study of 248 gastric specimens, examinated and evaluated according Sydney to system. The prevalence of H. Pylori is 67 %, chronic gastritis is observed in all the biopsies (100%). Age and gender were not a risk factors for the H. Pylori infection. Prevalence of H. Pylori was 71.93% in low socio-economic class. The severity of the chronic gastritis increases if the colonization of H. Pylori increases. In 74, 58% of cases chronic gastritis was active. Glandular atrophy presented 10.37% and in 80% was related to H. Pylori infection (p=0,004) and 12 % related to autoimmune diseases. The prevalence of Intestinal metaplasia is 10.53%, and H. Pylori was observed in 42.31% of cases (p=0.001). The dysplasia is detected in one case, in a 72 years old patient. We also observed one case of gastric adenocarcinoma, of an 80 years. Follicular gastritis are in 32% of cases, and they were more frequent in H. Pylori infected slides (82% of subjects) (p< 0.005).According to this study, H. Pylori Chronic Gastritis is very common in our population, and a coherent relationship exists between H. Pylori colonization and pre-cancerous lesions. An early eradicating should be considered as a health goal.