Introduction: Prolonged rupture of membrane (PROM) is an important risk factor for early onset neonatal sepsis (EONS), which is associated with increased neonatal morbidity and mortality. This study is mainly done to know the outcome of neonates born to mothers with history of PROM. Methods: This study was conducted from January 2015 to December 2015 for a period of 12 months, in GSL medical college and hospital, Rajahmundry. Selection of cases-All the neonates born to mothers with history of prolonged rupture of membranes >18hrs were included in our study. Required investigations were done and followed during their hospital stay. Results: Out of 200 neonates born to mothers with PROM, 60 had clinical sepsis, 29 had confirmed sepsis. Out of 29 confirmed cases of sepsis, positive blood culture was seen in 22 cases. The incidence of EONS in present study was found to be 14.5%. In present study neonatal sepsis had a higher rate of incidence in preterm neonates (61.5%) than in term neonates (38.5%). The incidence of neonatal sepsis was found to be lower in neonates born to mothers who took prenatal antibiotic treatment (9.25%) as compared to neonates born to mothers who did not receive prenatal antibiotic treatment (20.65%). Respiratory distress was the commonest presenting clinical sign (33 cases). Out of all the five Sepsis screen parameters C-Reactive Protein has the highest sensitivity (90.90%). Conclusion: Preventive measures should focus on recognition of these high-risk infants with prompt laboratory screening for sepsis and early institution of empirical antibiotic based on local data

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