SUMMARY It has been known for many years that endocrine disorders have been found in women with rosacea. This disease is found more commonly in women who have menstrual abnormalities, or who are postmenopausal. There is, however, a paucity of adequate reports on the effect of simple hormonal therapy in the treatment of rosacea. This has prompted a systematic, longterm study of the influence of an oral ovulation inhibitor, namely Ovosiston, on this unpleasant and unsightly disorder.

There have been great political, social and economic changes in Bulgaria since 1990 with higher incidences of syphilis when compared with the previously controlled morbidity of syphilis. There has been a 7-fold increase in 1998 compared with 1990. The male/female ratio remained the same 1.2:1. A higher number of cases was reported in cities than in villages and small towns, 80.68% in 1990; 73.4% in 1998. The number of employed patients with syphilis has decreased during the years--from 75.5% in 1990 to 44% in 1998, with a corresponding increase in syphilis in the unemployed. The age group at highest risk is 20-24 years, 28.7% in 1991; 24% in 1998. The least affected group are those older than 55--the incidence being 6.34% in 1990; 2.6% in 1997 and 4% in 1998. The prevalence of the different stages of early infection remained the same. The incidence of congenital syphilis increased from 1 in 1990 and 1991 to 21 in 1996, 29 in 1997 and 35 in 1998.

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Computed tomography (CT) is widely accepted imaging modality used to detect recurrent colorectal cancer (CRC) in the routine follow up, though further imaging may be required. The objective of this research is to investigate the value of PET/CT in detecting colorectal cancer recurrence despite negative CT findings.A retrospective review of colorectal cancer patients referred for 18F-FDG PET/CT imaging to the University institute of positron emission tomography in Skopje, between July 2018 and January 2020. All of the patients had a stage III disease and were clinically suspicious of recurrence (elevated CEA or presence of symptoms) despite recent negative CT findings.Twenty one patients (10 women and 11 men, mean age 56.95) met the above criteria. In 6 patients (28%) cancer recurrence was detected. Negative PET/CT findings were reported in eleven patients and in only one patient (1/11, 9%) recurrence was detected within one year of PET/CT. Equivocal PET/CT finding were reported in three patients, further work-up proved metastasis. In eight (8/9, 88%) patients with abnormal level of CEA, PET/CT detected or initiated further work-up that led to malignancy detection. Patients with stage III CRC had the most positive PET/CT findings 4/7 (57%) compared to others. PET/CT could detect disease recurrence in patients when clinically suspicion persists in spite of negative CT findings.Elevated CEA and the primary tumor stage were dominant features of the patients with recurrent disease. Negative predictive value of PET/CT is high enough to reassure clinicians and reduce patient anxiety.