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This paper presents a new approach to evaluation of registration using a general discriminative learning model that is independent of the type of registration method. We select features by association of a registration with a set of metrics (pixel based, patch based and histogram based statistics) and learn a classifier that discriminates mis-registrations from correct registrations using Adaboost. Experiments on a set of wireless capsule endoscopy (CE) images and images extracted from minimally invasive surgical endoscopic video data are presented. Results show that the proposed method outperforms any single classifier.