Background:Recent brain imaging and electrophysiological studies have consistently shown dysfunction of the fronto-striatal thalamic pathways in patients with obsessive–compulsive disorder (OCD).Aim:To study the relationship of neuropsychological disposition with the executive functions and cognitive style in patients with OCD.Methods:Twenty OCD patients (14 males, 6 females) and 20 normal control subjects, matched for all relevant variables including age, sex and education, were studied. Neuropsychological disposition was assessed on the Adult Neuropsychological Questionnaire (ANQ), the executive functions were assessed through Wisconsin Card Sorting Test (WCST), and the cognitive style was assessed by employing the Embedded Figure Test (EFT).Results:Subcortical–cerebellar–spinal domain of ANQ was found to be associated with cognitive style and executive functions.Conclusion:The impairment of executive functions and poor activation of specific neurological circuitry in OCD patients affirms the neurobiological basis of the disorder.

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The present study aims to probe into the status of the big five personality factors in the OCD probands and their first degree relatives (FDR) viz a viz community controls and also look into the association of the big five factors with symptom severity and obsessive personality traits. Fifty dyads of probands and FDR and community controls matched on the basis of age, sex and education were assessed on NEO Five Factor Inventory, Yale Brown Obsession Compulsion Scale, Beck Depression Inventory and Leyton Obsessional Inventory to fulfill the aims of the study. The findings reveal higher neuroticism and lower extroversion and conscientiousness in the OCD group as compared to controls, endorsement of greater conscientiousness among the FDR as compared to the case-probands, with Agreeableness and Conscientiousness emerging as predictors associated with obsessive symptoms among OCD probands.

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