The present study describes the preparation of novel salt of Tinidazole (TN) with p-Toluenesulfonic acid (PTSA) that display enhanced solubility and antibacterial activity in Bacillus. The salt was prepared by solvent-drop grinding and characterised by powdered X-Ray diffraction, thermal analysis, Fourier transformation infrared spectroscopy (FT-IR) and polarized microscopy. FT-IR data confirms Tinidazole salt with p-Toluenesulfonic acid (TN-PTSA). Powdered X-ray diffraction and thermal analysis data reveals that both TN and TN-PTSA are crystalline nature. From microscopic photographs of polarized microscopy, crystals of TN-PTSA are rod shape whereas crystals of TN are plate shape. Solubility measurement of TN-PTSA on UV spectrophotometer showed solubility improvement compared with TN by 49.7 times in water. Antibacterial test showed higher activity in TN-PTSA to the Gram-positive bacillus bacteria as compared to the TN. This study demonstrates that TN-PTSA can be a potential substitute to the TN in the treatment of infection with Gram-positive bacillus bacteria.

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